Weight Loss

Glycemic Load, Weight Loss and Cardiovascular Disease Risk
Heart 01 Jan 2013

Glycemic Load, Weight Loss and Cardiovascular Disease Risk

To investigate the hypothesis that reducing the glycemic load of the diet will improve changes in body composition and cardio-vascular risk factors. The study compares a conventional reduced-fat, high carbohydrate diet with 3 means of reducing glycemic load: changing the carbohydrates to low-GI choices, replacing some of the carbohydrate with…
CAROLINA: Cardiovascular Outcome Study of Linagliptin versus Glimepiride in Patients with Type 2 Diabetes
Heart 01 Jan 2013

CAROLINA: Cardiovascular Outcome Study of Linagliptin versus Glimepiride in Patients with Type 2 Diabetes

The aim of the study is to investigate the long-term impact on cardiovascular morbidity and mortality, relevant efficacy parameters (e.g., glycaemic parameters) and safety (e.g., weight and hypoglycaemia) of treatment with linagliptin in patients with type-2 diabetes at elevated cardiovascular risk receiving usual care, and compare outcome against glimepiride. Official…
Effect of Abdominal Obesity on Lipoprotein Metabolism
Heart 01 Jan 2013

Effect of Abdominal Obesity on Lipoprotein Metabolism

Abdominal obesity is strongly associated with dyslipidemia, which may account for the associated increased risk of atherosclerosis and coronary disease. Hypothesis: Reduction in abdominal fat mass by weight loss decreases apoB concentration and raises HDL-cholesterol chiefly by increasing LDL-apoB fractional catabolic rate (FCR), as well as decreasing HDL apoA-I, respectively.
Metabolic Phenotyping of Individuals Born Following Assisted Reproduction Techniques (IMPART)
Children's health 01 Jan 2013

Metabolic Phenotyping of Individuals Born Following Assisted Reproduction Techniques (IMPART)

This study is to compare the effects of high-fat overfeeding on metabolic risk factors in children born through assisted reproduction technologies (ART) versus children conceived naturally (controls). We will utilise state of the art measures to characterise the physiological, endocrine and molecular responses to high fat overfeeding. The investigators…
Multicomponent Risk Factor Intervention for People With a Severe Mental Illness: a Feasibility Study
Mental Health 01 Jan 2013

Multicomponent Risk Factor Intervention for People With a Severe Mental Illness: a Feasibility Study

This study is a feasibility study of a multi-component intervention to enhance healthy living among young people with psychotic disorders, specifically targeting smoking and weight. Official Title Multicomponent Risk Factor Intervention for People With a Severe Mental Illness: a Feasibility Study Conditions Psychotic Disorder Obesity Addictive Behavior Study Type Interventional…
Lungs 01 Jan 2013

Randomised Study of a Simple Weight Loss Program for Obese Patients With Obstructive Sleep Apnoea

The purpose of the study is to determine if weight loss interventions aimed at lifestyle modification (dietary education, food diary pedometer) result in weight loss in patients with mild-moderate obstructive sleep apnoea (OSA) when compared to usual patient care. The secondary purpose of the study is to determine if the…
Research and Trials 01 Jan 2013

Cognitive Behavioural Therapy for Obesity

The purpose of this study is to evaluate the effectiveness of a cognitive behavioural treatment (CBT) designed to help obese patients lose weight and to maintain their weight losses over time. It is hypothesized that CBT will result in greater sustained weight loss compared to a standard behavioural weight loss…
Gastro 01 Jan 2013

Incisionless Treatment for Patients With Inadequate Weight Loss Following Roux-en-Y Gastric Bypass

It is estimated that up to 20% of patients who have Roux-en-Y Gastric Bypass (RYGB) surgery will not meet their weight loss goal, or may even regain some of the weight they initially lost. One possible explanation is that the opening between the stomach pouch and the intestine becomes stretched.
High Density Lipoprotein Turnover
Blood 01 Jan 2013

High Density Lipoprotein Turnover

The objective of the study is to evaluate the effect of Rimonabant 20mg in comparison to placebo, on HDL and VLDL lipoprotein kinetics, over a 12 months period. Official Title A Randomized, Double-Blind, Two Arm, Parallel, Placebo Controlled Study of Rimonabant 20 mg Effect on High Density Lipoprotein Kinetics in…