The purpose of the study is to compare the efficacy of levosimendan with that of dobutamine in patients with unstable hemodynamics (shock).

Official Title

Efficacy of Levosimendan in the Critically Ill Patients with Unstable Hemodynamics (the LICI study) – A Double Blind Randomized Pilot Study

Conditions

– Cardiogenic Shock- Septic Shock

Study Type

Interventional

Study Design

Treatment, Randomized, Double-Blind, Active Control, Parallel Assignment, Efficacy Study

Further Details

Primary Outcomes: Resolution of shock stateSecondary Outcomes: Change in cardiac functions

Study Start

Study start: October 2004; Expected completion: June 2006

Eligibility & Criteria

Inclusion Criteria:- Reduced left ventricular systolic function – Hypotension – Anuria or oligouria Exclusion Criteria:- Less than 18 years old – Pregnant – Uncorrected valvular stenosis – Hypertrophic obstructive cardiomyopathy (HOCM) – Third degree AV block

Total Enrolment

40

Contact Details

Intensive Care Unit, Nepean Hospital, Penrith, New South Wales, 2750, Australia; Recruiting:- Anthony S McLean, MD +61-2-47342490 mcleana@wahs.nsw.gov.au – Stephen J Huang, PhD +61-247342320 huangs@wahs.nsw.gov.au