The purpose of this study is to determine how common low levels of magnesium are in patients with end stage liver disease. In addition, investigator is trying to determine if low levels of magnesium affect the release of parathyroid hormone in patients with end stage liver disease and low vitamin D levels.

Official Title

Hypovitaminosis D and an Inadequate PTH Response in Chronic Liver Disease Patients.


  • Chronic Liver Disease
  • Hypovitaminosis

Study Type


Study Design

Diagnostic, Open Label, Active Control, Single Group Assignment, Efficacy Study.



Further Details

Primary Outcome Measures:

  • Perform a standard magnesium loading test to determine urinary magnesium retention in order to define prevalence of magnesium insufficiency in a chronic liver disease population
    [Time Frame: One month]
    [Designated as safety issue: No]

Secondary Outcome Measures:

  • Evaluate the effects of intravenous magnesium loading on the calcium-PTH endocrine axis by measuring pre and immediate post infusion calcium and PTH
    [Time Frame: One month]
    [Designated as safety issue: No]

Study Start

January 2008

Eligibility & Criteria

  • Ages Eligible for Study: 18 years and older
  • Genders Eligible for Study: Both
  • Accepts Healthy Volunteers: No

Inclusion Criteria:

  • Chronic liver disease patients > 18 years of age

Exclusion Criteria:

  • Subjects with known parathyroid disease
  • Subjects taking magnesium supplementation

Total Enrolment

Contact Details

Rajib Bhattacharya, (MD)
University of Kansas  


University of Kansas Medical Center
Kansas City, Kansas
United States, 66160

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