This randomized phase III trial is studying different combination chemotherapy regimens to see how well they work when given with or without peripheral stem cell transplantation, radiation therapy, and/or surgery in treating patients with Ewing’s sarcoma

Official Title

EURO-E.W.I.N.G. 99 – European Ewing Tumour Working Initiative of National Groups – Ewing Tumour Studies 1999 – EE 99


Ewing’s Sarcoma

Study Type


Study Design

Treatment, Randomized, Active Control

Further Details

Primary Outcome Measures:

  • Event-free survival
  • Overall survival

Secondary Outcome Measures:

  • Feasibility, toxicity, and response at 1 month following induction therapy
  • Feasibility and toxicity of consolidation regimens at 1 month following consolidation therapy

Study Start

February 2001 to approximately 2008

Eligibility & Criteria

  • Ages Eligible for Study: up to 49 Years
  • Genders Eligible for Study: Both

Inclusion Criteria:

  • Histologically confirmed tumor of the Ewing’s family of bone or soft tissue (Ewing’s sarcoma or Peripheral primitive neuroectodermal tumor)
  • Disease meeting one of the following criteria: Resectable localized disease (tumor volume less than 200 mL); Localized disease previously resected at diagnosis; Unresectable disease (at least 200 mL tumor volume) but radiotherapy as local control can be delayed; Localized disease with early radiotherapy required; Pulmonary and/or pleural metastases only; Extrapulmonary/pleural metastases (skeleton, bone marrow, lymph nodes)
  • No more than 45 days since definitive biopsy
  • Age: Under 50
  • Renal: Renal function normal; Glomerular filtration rate at least 60 mL/min
  • Cardiovascular: Normal cardiac function; Fractional shortening at least 29%; Ejection fraction at least 40%
  • No prior chemotherapy
  • No medical, psychiatric, or social condition that would preclude study participation

Total Enrolment


Contact Details

Westmead Institute for Cancer Research at Westmead Hospital, Westmead, New South Wales, 2145, Australia; Recruiting

  • Geoffrey McCowage 61298452122

Royal Children’s Hospital, Herston, Brisbane, Queensland, 4029, Australia; Recruiting

  • Helen Irving 617-3636-8671

Women’s and Children’s Hospital, North Adelaide, South Australia, 5006, Australia; Recruiting

  • Maria L. Kirby 61881617411

Princess Margaret Hospital for Children, Perth, Western Australia, 6001, Australia; Recruiting

  • David Baker 011-6189340-8234

Further information from The National Cancer Institute

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