In overweight patients with chronic heart failure, to compare the effects of a modified fat diet with reduced glycaemic load (diet 1), and a conventional low fat, high carbohydrate diet (diet 2) on: insulin sensitivity (using the HOMA model); lipid profile; symptomatic status ( 6 minute walk distance and heart failure quality of life (HF QOL) questionnaire ); body weight; inflammatory mediators ( Tumor Necrosis Factor alpha, CRP, Interleukin 6 ).
The Hypotheses of this study are: Diet 1 will be associated with lower insulin resistance than diet 2; The lipid profile will be better in CHF patients on diet 1 than diet 2; Patients on diet 1 will have better symptomatic status than patients on diet 2; Diet 1 will maintain body weight in patients with CHF as well as diet 2; Diet 1 will suppress the expression of TNF-alpha, CRP and IL-6 more than diet 2.
Can a Modified Fat Diet With Low Glycaemic Load Improve Insulin Sensitivity and Inflammatory Mediators in Overweight People With Chronic Heart Failure?
Educational/Counseling/Training, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study
- Primary Outcome Measures: BMI; Blood Lipids; Inflammatory mediators; HOMA
- Secondary Outcome Measures: Heart Failure Quality of Life Questionnaire; 6 minute walk test
January 2005; Expected completion: September 2005
Eligibility & Criteria
- Ages Eligible for Study: 18 Years – 75 Years
- Genders Eligible for Study: Both
- English speaking Heart failure patients (NYHA Classes 1 – 3) attending the Alfred Hospital outpatient clinic will be enrolled.
- Patients will be excluded if they are below the healthy weight range (BMI<25kg/m2) or if they are morbidly obese (BMI>35 kg/m2).
- Patients with heart failure New York Heart Association (NYHA) Class 4 will be excluded due to their increased risk of developing cachexia.
Alfred Hospital, Melbourne, Victoria, 3004, Australia
- Fiona J Adams, BSc.GDip.Diet +613 9276 3063 Ext. 3063 firstname.lastname@example.org
- Rachel M Stoney, BSc.MDiet.PhD +613 9276 3063 Ext. 3063 email@example.com