In overweight patients with chronic heart failure, to compare the effects of a modified fat diet with reduced glycaemic load (diet 1), and a conventional low fat, high carbohydrate diet (diet 2) on: insulin sensitivity (using the HOMA model); lipid profile; symptomatic status ( 6 minute walk distance and heart failure quality of life (HF QOL) questionnaire ); body weight; inflammatory mediators ( Tumor Necrosis Factor alpha, CRP, Interleukin 6 ).

The Hypotheses of this study are: Diet 1 will be associated with lower insulin resistance than diet 2; The lipid profile will be better in CHF patients on diet 1 than diet 2; Patients on diet 1 will have better symptomatic status than patients on diet 2; Diet 1 will maintain body weight in patients with CHF as well as diet 2; Diet 1 will suppress the expression of TNF-alpha, CRP and IL-6 more than diet 2.

Official Title

Can a Modified Fat Diet With Low Glycaemic Load Improve Insulin Sensitivity and Inflammatory Mediators in Overweight People With Chronic Heart Failure?

Conditions

Heart Failure

Study Type

Interventional

Study Design

Educational/Counseling/Training, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study

Further Details

  • Primary Outcome Measures: BMI; Blood Lipids; Inflammatory mediators; HOMA
  • Secondary Outcome Measures: Heart Failure Quality of Life Questionnaire; 6 minute walk test

Study Start

January 2005; Expected completion: September 2005

Eligibility & Criteria

  • Ages Eligible for Study: 18 Years – 75 Years
  • Genders Eligible for Study: Both

Inclusion Criteria:

  • English speaking Heart failure patients (NYHA Classes 1 – 3) attending the Alfred Hospital outpatient clinic will be enrolled.

Exclusion Criteria:

  • Patients will be excluded if they are below the healthy weight range (BMI<25kg/m2) or if they are morbidly obese (BMI>35 kg/m2).
  • Patients with heart failure New York Heart Association (NYHA) Class 4 will be excluded due to their increased risk of developing cachexia.

Total Enrolment

50

Contact Details

Alfred Hospital, Melbourne, Victoria, 3004, Australia

  • Fiona J Adams, BSc.GDip.Diet +613 9276 3063 Ext. 3063 f.adams@alfred.org.au
  • Rachel M Stoney, BSc.MDiet.PhD +613 9276 3063 Ext. 3063 r.stoney@alfred.org.au