Research and Trials

Blood 01 Jan 2013

Study to Determine the Effect and Safety of an Oral Janus Kinase 2 (JAK2)-Inhibitor in Patients with Multiple Myeloma

The purpose of this study is to determine clinical efficacy and safety of INCB018424, a small molecule Janus kinase (JAK) inhibitor, in patients with refractory or relapsed multiple myeloma. Official Title A Phase 2, Two Stage, Open-Label, Clinical Trial to Determine the Therapeutic Effect and Safety of an Oral JAK2-Inhibitor…
Hormones 01 Jan 2013

Growth Hormone as a Determinant of Weight Regulation

With the alarming increase in the prevalence of obesity, identifying factors that predispose individuals to weight-gain is of critical importance. Even when caloric intake and physical activity levels are well controlled, susceptibility for weight-gain is heterogeneous. Basal metabolic rate (BMR) represents the largest portion of daily energy expenditure in normal…
Cancer 01 Jan 2013

Bortezomib in Treating Patients With Newly Diagnosed High-Risk Stage III Multiple Myeloma

RATIONALE: Bortezomib may stop the growth of cancer cells by blocking the enzymes necessary for their growth. PURPOSE: This phase II trial is studying how well bortezomib works in treating patients with newly diagnosed high-risk stage III multiple myeloma. Official Title Phase II Study Of PS-341 For Patients With…
Cancer 01 Jan 2013

A Study of LY573636 in Treating Patients With Malignant Melanoma

The primary objective of this study is to determine the objective response rate (complete and partial response) for patients who receive LY573636 after one prior systemic treatment for unresectable or metastatic melanoma. Official Title A Phase 2 Study of LY573636 Administered as an Intravenous Infusion on Day 1 of a…
Multicomponent Risk Factor Intervention for People With a Severe Mental Illness: a Feasibility Study
Mental Health 01 Jan 2013

Multicomponent Risk Factor Intervention for People With a Severe Mental Illness: a Feasibility Study

This study is a feasibility study of a multi-component intervention to enhance healthy living among young people with psychotic disorders, specifically targeting smoking and weight. Official Title Multicomponent Risk Factor Intervention for People With a Severe Mental Illness: a Feasibility Study Conditions Psychotic Disorder Obesity Addictive Behavior Study Type Interventional…
Mental Health 01 Jan 2013

Use of Quetiapine as an Add on Therapy in the Treatment of Post Traumatic Stress Disorder

The purpose of this study is to evaluate how effective quetiapine versus placebo is when added to an existing therapy, in reducing the symptoms of PTSD. Official Title A Multicentre, Parallel Group, Randomised, Double Blind, Placebo Controlled Study of the Use of Quetiapine as an Add on Therapy in the…
Gastro 01 Jan 2013

A Study to Evaluate the Efficacy and Safety of CCX282-B in Subjects With Moderate to Severe Crohn’s Disease

The purpose of this study is to determine whether CCX282-B is effective in treating patients with moderate to severe Crohn’s Disease. Official Title A Multinational, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of CCX282-B in Subjects With Moderate to Severe Crohn’s Disease Conditions Crohn’s Disease…
Blood 01 Jan 2013

Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Recurrent or Refractory Hodgkin’s or Non-Hodgkin’s Lymphoma

Phase II trial to study the effectiveness of combination chemotherapy followed by peripheral stem cell transplantation in treating children who have recurrent or refractory Hodgkin’s lymphoma or non-Hodgkin’s lymphoma. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Peripheral stem…
Efficacy and Safety Study of Combined Oral and Injection Therapy for Erectile Dysfunction
Men's Health 01 Jan 2013

Efficacy and Safety Study of Combined Oral and Injection Therapy for Erectile Dysfunction

Aim of the study is to test the safety and efficacy of a combination of Viagra and Caverjet Impulse in a group of men who had failed to achieve an adequate response to the maximum recommended dose of either Viagra, Cialis or Levitra and Caverjet Impulse, when these treatments were…