This study seeks to document differences in nasal irritant sensitivity within the population. We are interested in knowing whether age, gender, and allergy status (nasal allergies) predict nasal irritant sensitivity. This is important in understanding symptom reporting patterns in air pollution situations (particularly in so-called “problem buildings”), as well as in understanding reflex mechanism of response of the nose to irritants (e.g., nasal congestion).

Official Title

Individual Factors in Nasal Irritant Sensitivity


– Rhinitis, Allergic, Nonseasonal

Study Type


Study Design

Randomized, Single Blind, Crossover Assignment

Further Details

Study Start

Eligibility & Criteria

Ages Eligible for Study: 18 Years – 69 Years, Genders Eligible for Study: Both Accepts Healthy VolunteersCriteria Non-smokers 18-69 years of age, with or without allergic rhinitis (hay fever), in good general health and with no prior history of asthma.

Total Enrolment


Contact Details

[1] National Institute of Environmental Health Sciences (NIEHS)